Lamin A

Lamin A: Abbreviated LMNA. A gene on chromosome 1 that encodes a protein which is a key component of the membrane surrounding the cell nucleus.

Mutations in the LMNA gene are responsible for a number of genetic disorders including: Progeria syndrome, Emery-Dreifuss muscular dystrophy type 2, Limb girdle muscular dystrophy type 1B, Charcot-Marie-Tooth disorder type 2B1, The Dunnigan type of familial partial lipodystrophy, Mandibuloacral dysplasia and A familial form of dilated cardiomyopathy.